HER2-low metastatic breast cancer patients report preserved quality of life with trastuzumab deruxtecan treatment

Patients who received trastuzumab deruxtecan (T-DXd) for human epidermal growth factor receptor 2 (HER2)-low metastatic breast cancer reported that the treatment maintained their quality of life (QoL) compared to conventional chemotherapy, according to results presented today by researchers from The University of Texas MD Anderson Cancer Center at the European Society for Medical Oncology (ESMO) […]

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TAVR is an affordable and effective strategy for treating aortic stenosis patients

Minimally invasive, catheter-based transcatheter aortic valve replacement (TAVR) has revolutionized treatment of aortic stenosis (AS), and both American and European guidelines have approved its use. However, there is a perception that TAVR is more expensive than surgical aortic valve replacement (SAVR). A budget impact analysis comparing the two options now shows that TAVR is an […]

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New study reveals a widening gap in diabetes-related mortality between urban and rural areas in the US

A new study published in Diabetologia finds that there is a widening gap in diabetes-related mortality between urban and rural areas in the U.S., and that reductions in mortality rates seen predominantly in urban areas have been mainly limited to female and older patients while outcomes in male and younger individuals worsened. The research was […]

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Neoadjuvant immunotherapy improves outlook in high-risk melanoma

Patients with high-risk melanoma who received the immunotherapy drug pembrolizumab both before and after surgery to remove cancerous tissue had a significantly lower risk of their cancer recurring than similar patients who received the drug only after surgery. These results from a research study by the SWOG Cancer Research Network, a cancer clinical trials group […]

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Blocking FNDC5, the precursor of the exercise hormone irisin, protects mice from cancer-induced cachexia

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found. When cancer patients develop cachexia, their bodies waste away. Cachexia is marked by extreme fatigue, weight […]

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Study finds antibiotics may make melanoma worse, by depleting the gut microbiome

The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice’s intestinal flora and weakened their immune response, according to a new study by researchers at Emory University in Atlanta. The findings underscore the importance of the gut […]

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